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Biometric Research Program (BRP)

Dr. Mariam Konate Monnard

Computational Biologist, Computational & Systems Biology Branch


Research Interests

Biomarker discovery, integrative genomics, cancer epigenetics, gene expression analysis, structural bioinformatics


Selected Recent Publications:

Navas T, Kinders RJ, Lawrence SM, Ferry-Galow KV, Borgel S, Hollingshead MG, Srivastava AK, Alcoser SY, Makhlouf HR, Chuaqui R, Wilsker DF, Konate MM, Miller SB, Voth AR, Chen L, Vilimas T, Subramanian J, Rubinstein L, Kummar S, Chen AP, Bottaro DP, Doroshow JH, Parchment RE. Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas. Cancer Res, pii, 2019.

Wu Y, Konate MM, Lu J, Makhlouf H, Chuaqui R, Antony S, Meitzler JL, Difilippantonio MJ, Liu H, Juhasz A, Jiang G, Dahan I, Roy K, Doroshow JH. IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells. J Immunol, ji1800469, 2019.

Konate MM, Plata G, Park J, Usmanova DR, Wang H, Vitkup D. Molecular function limits divergent protein evolution on planetary timescales. Elife, 8: e39705, 2019.

Meitzler JL, Konate MM, Doroshow JH. Hydrogen peroxide-producing NADPH oxidases and the promotion of migratory phenotypes in cancer. Arch Biochem Biophys, Aug 12: 108076, 2019.

Monks A, Zhao Y, Hose C, Hamed H, Krushkal J, Fang J, Sonkin D, Palmisano A, Polley E, Fogli L, Konate M, Miller S, Simpson M, Voth A, Li M-C, Harris E, Wu X, Connelly J, Rapisarda A, Teicher B, Simon R, Doroshow JH. The NCI Transcriptional Pharmacodynamics Workbench: a tool to examine dynamic expression profiling of therapeutic response in the NCI-60 cell line panel. Cancer Research, 78: 6807-6817, 2018.

Antony S, Jiang G, Wu Y, Meitzler JL, Makhlouf HR, Haines DC, Butcher D, Hoon DS, Ji J, Zhang Y, Juhasz A, Lu J, Liu H, Dahan I, Konate M, Roy KK, Doroshow JH. NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1α and p27Kip1 expression in malignant melanoma and other human tumors. Molecular Carcinogenesis, 56:2643-2662, 2017.

Lu J, Risbood P, Kane CT Jr, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A, Liu H, Jiang G, Harris E, Roy K, Meitzler JL, Konate M, Doroshow JH. Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases. Biochemical Pharmacology, 143:25-38, 2017.

Gallagher SS, Jing C, Peterka DS, Konate M, Wombacher R, Kaufman LJ, Yuste R, Cornish VW. A trimethoprim-based chemical tag for live cell two-photon imaging. Chembiochem, 11:782-784, 2010.



Dr. Mariam Konate

Office Address:
Room 5W116
9609 Medical Center Dr
Rockville, MD 20850

Contact Information:
Tel: (240) 276-6273
Fax: (240) 276-7888
Email:mariam.konate@nih.gov