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Biometric Research Program (BRP)

Welcome to the Biometric Research Program

The Biometric Research Program consists of a Biostatistics Branch and a Computational & Systems Biology Branch. The Biostatistics Branch provides statistical leadership and oversight for the national program of therapeutic and diagnostic clinical trials of the National Cancer Institute as well as translational research in developmental therapeutics, diagnostics and cancer imaging. The Biostatistics Branch also conducts research in methods for the design, monitoring and analysis of clinical trials and related studies. It consists of doctoral level statisticians.

The Computational & Systems Biology Branch collaborates in the pre-clinical programs of the DCTD to utilize genomic and proteomic technology to identify molecular targets, resistance mechanisms and effective new drugs, drug combinations and biomarkers for guiding treatment. Members of the Computational & Systems Biology Branch conduct research on mechanisms of carcinogenesis and systems pharmacology. The branch develops bioinformatic systems to support genomic variant based clinical trials and to enhance the ability of biologists and pharmacologists to analyze and interpret genome-wide data. The branch also collaborates in the analysis of genomic data from the clinical trials program of the NCI. The Computational & Systems Biology Branch consists of doctoral level staff with diverse backgrounds such as computational biology, bioinformatics, computer science, biology, pharmacology, medicine and biomedical engineering.

The philosophy of the Biometric Research Program is to have the staff combine two functions: (i) collaboration and consultation with the staff of the DCTD and intramural investigators of the NCI; and (ii) conduct self-initiated research on topics important to cancer research. Combining these functions has enabled the program to recruit and retain an expert staff and to provide the highest quality collaborations to DCTD and NCI scientists. It has also enabled the program to conduct research that has impacted the field and is motivated by key problems of current cancer research. The program does not have a grant, cooperative agreement or contract portfolio and does not sponsor extramural research.

Associate Director

Dr. Lisa McShane, Acting Associate DirectorDr. Lisa Meier McShane, the Acting Associate Director, leads the Biometric Research Program, Division of Cancer Treatment and Diagnosis, U.S. National Cancer Institute, National Institutes of Health. She was formerly Chief of the Biostatistics Branch within the program and now has oversight and strategic planning responsibilities for both branches in the program, including additionally the Computational and Systems Biology Branch. She holds a doctoral degree in Statistics from Cornell University in Ithaca, NY and is an elected Fellow of the American Statistical Association. She is a recognized expert in development of tumor marker-based tests for prognosis, therapy selection, and disease monitoring. More…

News

Dr. Richard Simon has officially announced his retirement from the National Cancer Institute on July 1, 2017 after 47 years of service in NIH.

Dr. Lisa McShane has been appointed as the Acting Associate Director of DCTD to lead the Biometric Research Program.

Dr. Richard Simon is the 2017 recipient of the Melvin Zelen Leadership Award in Statistical Science from the Department of Biostatistics at the Harvard T.H. Chan School of Public Health. Dr. Simon received the award in person on May 18, 2017 and presented a lecture entitled, "Translating Genomics to Personalized Oncology: Key Contributions of Statistical Scientists".