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Biometric Research Program (BRP)

Dr. Ana Best

Mathematical Statistician, Biostatistics Branch


Research Interests

Biomarkers in clinical trials, study design, survival analysis, risk prediction, cancer surveillance


Selected Publications:

Stewart DR, Best AF, Williams GM, Harney LA, Carr AG, Harris AK, Kratz CP, Dehner LP, Messinger YH, Rosenberg PS, Hill DA, Schultz KAP. Neoplasm risk among individuals with a pathogenic germline variant in DICER1. Journal of Clnical Oncology. 2019. 37 (8): 668-676. PMID: 30714996

Best AF, Tucker MA, Frone MN, Greene MH, Peters JA, Katki HA. A pragmatic testing-eligibility framework for population mutation screening: The example of BRCA1/2. Cancer Epidemiology Biomarkers and Prevention. 2019. 28 (2): 293-302. PMID: 30692095

Wolfson DB, Best AF, Addona V, Wolfson J, Gadalla SM. Benefits of combining prevalent and incident cohorts: An application to myotonic dystrophy. Statistical Methods in Medical Research. 2018 (Epub ahead of print). PMID: 30293502

Best AF, Hilbert JE, Wood L, Martens WB, Nikolenko N, Marini-Bettolo C, Lochm├╝ller H, Rosenberg PS, Moxley RT 3rd, Greene MH, Gadalla SM. Survival patterns and cancer determinants in families with myotonic dystrophy type 1. European Journal of Neurology. 2019. 26(1): 58-65. PMID: 30051542

Best AF, Haozous EA, Berrington de Gonzalez A, Chernyavskiy P, Freedman ND, Hartge P, Thomas D, Rosenberg PS, Shiels MS. Premature mortality projections in the USA through 2030: a modelling study. The Lancet Public Health. 2018. 3(8): e374-e385. PMID: 30037721

Best AF, Wolfson DB. Risk-set-sampling of left-truncated survival data. Canadian Journal of Statistics. 2017. 45(1): 4-28.

Ballinger ML, Best A, ..., Thomas DM, Savage SA. Baseline surveillance in Li-Fraumeni syndrome using whole-body magnetic resonance imaging: A meta-analysis. JAMA Oncology. 2017. 3(12): 1634-1639. PMID: 28772291

Mai PL, Best AF, Peters JA, DeCastro RM, Khincha PP, Loud JT, Bremer RC, Rosenberg PS, Savage SA. Risks of first and subsequent cancers among TP53 mutation carriersin the National Cancer Institute Li-Fraumeni syndrome cohort. Cancer. 2016. 122(23): 3673-3681: PMID: 27496082



Dr. Ana Best

Office Address:
Room 5W114
9609 Medical Center Dr
Rockville, MD 20850

Contact Information:
Tel: (240) 276-7808
Fax: (240) 276-7888
Email:ana.best@nih.gov