Research Interests
Statistical design and analysis
of microarray experiments for cancer research; causal inference for
clinical trials.
Selected Publications
As of March 10, 2006
Dobbin, K. and Simon, R. (in press) Statistical issues in
the interpretation and design of microarray experiments. In:
Bioinformatics in Cancer and Cancer Therapy. Humana
Press, New York.
Dobbin, K.K. and Simon, R.M. Sample size planning for
developing classifiers using high dimensional DNA microarray
data. In review.
Kajdacsy-Balla, A., Geynisman, J.M., Macias, V., Berman,
J.J., Dobbin, K., Melamed, J., Kong, X., Bosland, M., Orenstein,
J., Bayerl, J., Becich, M., Dhir, R., Datta, M.W. and the
Cooperative Prostate Cancer Tissue Resource (2006) Practical
aspects of planning, building and interpreting tissue
microarrays: the cooperative prostate cancer tissue resource
experience. Journal of Molecular Histology, in press.
Dobbin, K. and Simon, R. (2005) Experimental design
[Specialist Review]. In: Encyclopedia of Genetics, Genomics,
Proteomics and Bioinformatics. John Wiley and Sons, New
York. Book website:
http://www.mrw.interscience.wiley.com/ggpb/.
Dobbin, K.K., Shih, J.H. and Simon, R.M. (2005) Comment
on`Evaluation of the gene-specific dye bias in cDNA microarray
experiments'. Bioinformatics, 21, 2803-2804.
Dobbin, K.K., Kawasaki, E.S., Petersen, D.W., and Simon,
R.M. (2005) Characterizing dye bias in microarray experiments.
Bioinformatics, 21, 2430-2437.
Dobbin, K., Beer, D.G., Meyerson, M., Yeatman, T., Gerald,
W., Jacobson, J., Conley, B., Buetow, K., Heiskanen, M., Simon,
R., Minna, J., Girard, L., Misek, D., Taylor, J., Hanash, S.,
Naoki, K., Hayes, D. N., Ladd-Acosta, C., Enkemann, S., Viale, A.,
Giordano, T. (2005) Inter-laboratory comparability study of cancer
gene expression analysis using oligonucleotide microarrays.
Clinical Cancer Research, 11, 565-72.
Datta, M.W., Dhir, R., Dobbin, K., Melamed, J., Becich,
M.J., Orenstein, J.M., Kajdacsy-Balla, A.A., Bosland, M.C., Patel,
A., Macias, V., Berman, J.J., and the Cooperative Prostate Cancer
Tissue Resource (2005) Prostate cancer in patients with
pre-diagnostic serum PSA values less than 4.0 ng/dl: Results from
the Cooperative Prostate Cancer Tissue Resource . Journal
of Urology, 173, 1546-1551.
Dobbin, K. and Simon, R. (2005) Sample Size Determination
in Microarray Experiments for Class Comparison and Prognostic
Classification. Biostatistics, 6, 27-38.
Shih, J., Michalowska, A., Dobbin, K., Ye, Y., Qiu, T. and
Green, J. (2004) Effects of pooling mRNA in microarray class
comparisons. Bioinformatics, 18, 3318-3325.
Berman, J.J., Datta, M., Kajdacsy-Balla, A., Melamed, J., Orenstein, J.,
Dobbin, K., Patel, A., and Dhir, R. (2004) The tissue microarray data exchange
specification: implementation by the Cooperative Prostate Cancer Tissue Resource.
BMC Bioinformatics, 5, 19.
Dobbin, K., Shih, J.H. and Simon, R. (2003) Questions
and answers on design of dual-label microarrays for identifying differentially expressed genes,
Journal of the Natinoal Cancer Institute, 95, 1362-69.
Simon, R. and Dobbin, K. (2003) Experimental Design
of DNA Microarray Experiments, Biotechniques, March Supplement.
Dobbin, K. and Louis, T.A. (2003) Accommodating Stochastic
Departures from Percentile Invariance in Causal Models, Journal
of the Royal Statistical Society, Series B, 65, 1-13.
Dobbin, K., Shih, J. and Simon, R. (2003) Statistical
Design of Reverse Dye Microarrays, Bioinformatics, 19, 803-810.
Simon, R., Radmacher, M., Dobbin, K. and McShane,
L. (2003) Pitfalls in the Use of DNA Microarray Data for Diagnostic
and Prognostic Classification, Journal of the National Cancer
Institute, 95, 14-18.
Simon, R., Radmacher, M. and Dobbin, K. (2002) Design
of Studies Using DNA Microarrays, Genetic Epidemiology, 23,
21-36.
Dobbin, K. and Simon, R. (2002) Comparison of Microarray
Designs for Class Comparison and Class Discovery, Bioinformatics,
18, 1438-1445.
brb@linus.nci.nih.gov