Dr. Myong-Hee Sung Office Address: Room 8146 6130 Executive Plaza Rockville, MD 20852 Contact Information: Tel: (301) 402-0364 Fax: (301) 402-0560 Email:sungm@mail.nih.gov

Research Interests

• Computational systems biology of T lymphocytes and cancer cells
• Prediction of MHC binding peptides
• Analysis of T cell receptor stimulation data using combinatorial peptide libraries 
• Modeling and simulations of biochemical pathways as dynamical systems 
• Mathematical modeling of tumorigenesis and stem cell kinetics 
• DNA microarray data analysis

Resume (updated March, 2005)

Selected Publications 
As of March 31, 2005

Zhike Zi, Kwang-Hyun Cho , Myong-Hee Sung, Xuefeng Xia, and Zhirong Sun: In Silico Identification of the Key Components and Steps in IFN-? Induced JAK-STAT Signaling Pathway. FEBS Lett. (2005) 579 1101-1108. 

Myong-Hee Sung and Richard Simon: In Silico Simulation of Inhibitor Drug Effects on NF-KB Pathway Dynamics.  Molecular Pharmacology (2004) 66 no. 1, pp.70-75.

Sung, M.-H., Simon, R. Genome-wide Conserved Epitope Profiles of HIV-1 Predicted by Quantitative Properties of MHC Binding Peptides. J. Computational Biology Vol. 11, No. 1 (2004) pp.125-145.

B. Bielekova, M.-H. Sung, N. Kadom, R. Simon, H. McFarland, and R. Martin: Expansion and Functional Relevance of High-avidity Myelin-specific CD4+ T Cells in Multiple Sclerosis  J. Immunology 2004, 172 pp.3893-3904.

Myong-Hee Sung and Richard Simon: Candidate Epitope Identification Using Peptide Property Models: Application to Cancer Immunotherapy, special issue of Methods on "Bioinformatics in Vaccine Design"  2004, 34 no. 4 pp.460-467. 

D. B. Carr and M.-H. Sung: Graphs for Representing Statistics Indexed by Nucleotide or Amino Acid Sequences COMSTAT 2004, Proceeding in Computational Statistics, 16th Symposium, held in Prague Czech Rep. 2004, pp.73-84. 

Sung, M.-H., Zhao, Y., Martin, R., Simon, R. T-cell Epitope Prediction with Combinatorial Peptide Libraries. J. Computational Biology 9 No. 3 (2002) pp. 527-539. 

Martin, R., Gran, B., Zhao, Y., Markovic-Plese, S., Bielekova, B., Marques, A., Sung, M.-H., Hemmer, B., Simon, R., McFarland, H.F., Pinilla, C. Molecular Mimicry and Antigen-Specific T Cell Responses in Multiple Sclerosis and Chronic CNS Lyme Disease. J. Autoimmunity 16 (2001) pp. 187-192. 

Please send comments and suggestions to brb@linus.nci.nih.gov